RESUMO
UNLABELLED: Coronary artery disease (CAD) represents the principal cause of morbidity and mortality in our environment. Positron emission tomography (PET) is a new technique in our country that allows the assessment of myocardial perfusion and the absolute quantification of the coronary blood flow (CBF) through the utilization of radiotracers using the same criteria employed in conventional nuclear cardiology. CBF normal values have been determined in other populations around the world. No studies in our country assessing in a non-invasive way the CBF have been published before. The quantification of CBF in healthy population is important to establish a standard measure and determine through it, the effects of the many diseases that change the coronary blood flow. The quantification of the CBF, the calculation of coronary blood flow reserve (CFR) and the endothelium dependent vasodilatation index (EDVI) through PET is possible performing three different acquisition stages: rest, cold pressor test (CPT) and pharmacologic stress using Ammonia as radiotracer. The aim of this study was to evaluate the CBF, the CFR and the EDVI in healthy Mexican volunteers. RESULTS: Global basal CBF was 0.34 (+/- 0.09) mL/g/min, during CPT increased to 0.55 (+/- 0.17) mL/g/min and during the stress increased to 1.18 (+/- 0.25). CFR was 3.5 (+/- 0.65) and EDVI was 1.55 (+/- 0.33). CONCLUSIONS: CFR and EDVI values obtained in Mexican healthy population correlates very well with those reported in the literature. This values represents a reference to further research that use this technology.
Assuntos
Circulação Coronária , Tomografia por Emissão de Pósitrons , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , México , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
La enfermedad arterial coronaria (EAC) representa la primera causa de morbi mortalidad en nuestro medio. La tomografía por emisión de positrones (PET) es una técnica novedosa en nuestro país mediante la cual es posible valorar la perfusión miocárdica a través de radiotrazadores, lo que permite detectar defectos de perfusión utilizando los mismos criterios que en cardiología nuclear. A su vez, a través del estudio del flujo coronario (FC) es posible detectar la EAC en sus etapas más tempranas. El FC ha sido determinado en otras poblaciones a nivel mundial, sin embargo, hasta el momento no existen estudios en nuestro país que lo hayan valorado de manera no invasiva. La importancia de determinar el FC en voluntarios sanos radica en establecer una base para poder comparar estos resultados con los encontrados en pacientes con diferente patología que afecte el flujo coronario. Para la determinación del FC y la reserva de flujo coronario (RFC) y del índice de vasodilatación dependiente de endotelio (IVED) mediante PET se realizan 3 mediciones en 3 fases distintas: reposo, estimulación con frío (CPT) y esfuerzo farmacológico, con la utilización de amonio. Objetivo: Determinar el FC en las tres fases en población sana con la utilización de amonio-PET. Resultados: El FC global basal fue de 0.34 (±0.09) mL/g/min, durante el CPT incrementó a 0.55 (±0.17) mL/g/min y con el estrés llegó a 1.18 (±0.25). La RFC fue de 3.5 (±0.65) y el IVED de 1.55 (±0.33). Conclusiones: Los valores obtenidos de RFC y de IVED en población mexicana sana coincide con los reportados en la literatura. Estos valores representan una base de referencia para las investigaciones futuras con esta tecnología en nuestro país.
Coronary artery disease (CAD) represents the principal cause of morbidity and mortality in our environment. Positron emission tomography (PET) is a new technique in our country that allows the assessment of myocardial perfusion and the absolute quantification of the coronary blood flow (CBF) through the utilization of radiotracers using the same criteria employed in conventional nuclear cardiology. CBF normal values have been determined in other populations around the world. No studies in our country assessing in a non-invasive way the CBF have been published before. The quantification of CBF in healthy population is important to establish a standard measure and determine through it, the effects of the many diseases that change the coronary blood flow. The quantification of the CBF, the calculation of coronary blood flow reserve (CFR) and the endothelium dependent vasodilatation index (EDVI) through PET is possible performing three different acquisition stages: rest, cold pressor test (CPT) and pharmacologic stress using Ammonia as radiotracer. The aim of this study was to evaluate the CBF, the CFR and the EDVI in healthy Mexican volunteers. Results: Global basal CBF was 0.34 (±0.09) mL/g/min, during CPT increased to 0.55 (±0.17) mL/g/min and during the stress increased to 1.18 (±0.25). CFR was 3.5 (±0.65) and EDVI was 1.55 (±0.33). Conclusions: CFR and EDVI values obtained in Mexican healthy population correlates very well with those reported in the literature. This values represents a reference to further research that use this technology.
